Peyronie's Disease Treatment NYC

A curve that develops over time — and what causes it

Peyronie's disease is a buildup of fibrous scar tissue (a "plaque") inside the penis that causes a bend or curve, sometimes pain, and often difficulty with intercourse. It frequently goes hand-in-hand with erectile dysfunction. The good news: for most men it can be improved without surgery, and that's where we focus.

Xiaflex — the leading non-surgical treatment

How it works

Xiaflex (collagenase clostridium histolyticum) is the only FDA-approved injectable for Peyronie's disease. It's injected directly into the plaque, where the enzyme breaks down the collagen scar tissue that's causing the bend. Combined with penile modeling, a course of injections can meaningfully reduce curvature. It's an in-office treatment and a true alternative to surgery for appropriate men.

Experience that matters

Xiaflex is technique-dependent — where and how the plaque is injected, and how modeling is done, affects results. Dr. Shusterman has extensive hands-on experience with Xiaflex for Peyronie's, which is exactly the kind of procedure where an experienced injector makes a difference.

Low-intensity shockwave

We also offer low-intensity shockwave therapy (the same acoustic-wave technology behind our ErectionWave program) as part of a non-surgical approach — it can help with pain and is often combined with other treatment.

PRP (the "P-shot")

For some men we offer platelet-rich plasma (PRP), sometimes called the P-shot — an injection of concentrated growth factors from your own blood, used as part of a regenerative, non-surgical approach to curvature and function.

Why it matters

Done in the office, not the hospital

Because we have a combined urology and interventional radiology team in-office, we diagnose and treat the large majority of what we do right here — see how our in-office model works.

When to see us

If you've noticed a new curve, a lump you can feel, pain with erections, or difficulty with intercourse, it's worth an evaluation — earlier treatment often works better. Call (212) 991-9991 or book a consultation.

Common questions

Can Peyronie's disease be treated without surgery?

Non-surgical treatment may be appropriate for selected patients. Xiaflex is FDA-approved for adult men with a palpable plaque and penile curvature of at least 30 degrees when treatment begins. Eligibility, risks and alternatives require an individual assessment; treatment is not a guarantee of a particular result. A urologist can explain whether an injectable treatment or surgery is appropriate.

FDA: Xiaflex prescribing information (2023)

What is Xiaflex?

Xiaflex (collagenase clostridium histolyticum) is the only FDA-approved injectable for Peyronie's disease. It's injected into the plaque to break down the collagen scar tissue causing the curve, and is combined with penile modeling. Dr. Shusterman has extensive experience performing it.

Does Xiaflex hurt, and where is it injected?

It's an in-office injection placed directly into the Peyronie's plaque, not the rest of the penis. Most men tolerate it well; mild bruising or swelling can occur. The procedure itself takes only seconds per injection.

How much can the curve improve?

Results vary by individual, plaque, and degree of curvature, but studies of Xiaflex show meaningful average reductions in curvature, and an experienced injector helps optimize the outcome. We'll set realistic expectations based on your exam.

Is Peyronie's linked to erectile dysfunction?

Often, yes — the two frequently occur together. We evaluate and treat both, and can coordinate ED care including shockwave therapy and hormone optimization where appropriate.

Peyronie's Disease